Anti-ARRB1 Polyclonal Antibody (HW793014)

Name: Anti-ARRB1 Polyclonal Antibody
Brand: abinScience
SKU: HW793014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HW793014

설명

Anti-ARRB1 Polyclonal Antibody (HW793014) is a rabbit polyclonal antibody detecting ARRB1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human ARRB1 (Asp3-Thr246).

타겟

ARRB1, Beta-arrestin-1, Non-visual arrestin-2, ARR1, Arrestin beta-1

정제

Purified by antigen affinity column.

등록번호

P49407

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Beta-arrestin-1 (ARRB1) is a ~47 kDa protein. Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins.

1. Maharana, J. et al. (2023) Molecular cell 83, 2091-2107.e7. PMID: 37209686

2. Maharana, J. et al. (2024) Science (New York, N.Y.) 383, 101-108. PMID: 38175886

3. Puca, L. et al. (2013) Journal of cell science 126, 4457-68. PMID: 23886940

4. Lin, J. et al. (2025) Cell 188, 4530-4548.e25. PMID: 40446798

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-ARRB1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-ARRB1 Polyclonal Antibody (HW793014)

개요

이미지

참고 문헌

데이터시트

SDS