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| 카탈로그 번호 | HB310014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-ATP11A Polyclonal Antibody (HB310014) is a rabbit polyclonal antibody detecting Phospholipid-transporting ATPase IH; 7.6.2.1; ATPase IS; ATPase class VI type 11A; P4-ATPase flippase complex alpha subunit ATP11A; ATP11A; ATPIH; ATPIS; KIAA1021 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human ATP11A (Asp387-Lys860). | ||||||||
| 타겟 | Phospholipid-transporting ATPase IH; 7.6.2.1; ATPase IS; ATPase class VI type 11A; P4-ATPase flippase complex alpha subunit ATP11A; ATP11A; ATPIH; ATPIS; KIAA1021 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P98196, P98197 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Phospholipid-transporting ATPase IH (ATP11A) is a ~129 kDa protein. Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Does not show flippase activity toward phosphatidylcholine (PC). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation. May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. 1. Takatsu, H. et al. (2014) The Journal of biological chemistry 289, 33543-56. PMID: 25315773 2. Naito, T. et al. (2015) The Journal of biological chemistry 290, 15004-17. PMID: 25947375 3. Segawa, K. et al. (2016) The Journal of biological chemistry 291, 762-72. PMID: 26567335 4. Tsuchiya, M. et al. (2018) Nature communications 9, 2049. PMID: 29799007 5. Wang, J. et al. (2018) Scientific reports 8, 10795. PMID: 30018401 6. Chepurwar, S. et al. (2023) Human molecular genetics 32, 1083-1089. PMID: 36300302 7. Segawa, K. et al. (2021) The Journal of clinical investigation 131. PMID: 34403372 | ||||||||
| 참고사항 | For research use only |
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