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| 카탈로그 번호 | JN040033 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Bacillus anthracis | ||||
| 응용 분야 | ELISA, SPR | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a | ||||
| 클론 ID | E3# | ||||
| 타겟 | Calmodulin-sensitive adenylate cyclase, 4.6.1.1, ATP pyrophosphate-lyase, Adenylyl cyclase, Anthrax edema toxin adenylate cyclase component, Edema factor, EF, cya, pXO1-122, BXA0141, GBAA_pXO1_0142, Bacillus anthracis | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P40136 | ||||
| RRID | Anti-Bacillus anthracis cya/EF/Edema factor Antibody (E3#) (abinScience Cat# JN040033, RRID:AB_3729009) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Calmodulin-sensitive adenylate cyclase (cya/EF) is a ~92 kDa protein. Edema factor (EF), which constitutes one of the three proteins composing the anthrax toxin, causes edema in the host. Acts as a calmodulin-dependent adenylyl cyclase by converting ATP to cAMP, leading to dramatic elevation of intracellular cAMP levels in the host, thereby causing edema. EF is not toxic by itself and only acts as an edema factor when associated with protective antigen (PA) to form the edema toxin (EdTx). Required for the survival of germinated spores within macrophages at the early stages of infection. 1. Drum, CL. et al. (2002) Nature 415, 396-402. PMID: 11807546 2. Xia, ZG. et al. (1990) The Journal of biological chemistry 265, 6517-20. PMID: 2108958 3. Leppla, SH. (1982) Proceedings of the National Academy of Sciences of the United States of America 79, 3162-6. PMID: 6285339 4. Kumar, P. et al. (2001) Infection and immunity 69, 6532-6. PMID: 11553601 5. Guidi-Rontani, C. et al. (2001) Molecular microbiology 42, 931-8. PMID: 11737637 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Bacillus anthracis cya/EF/Edema factor Antibody (E3#)
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