Anti-BIRC5 Polyclonal Antibody (HT337014)

Name: Anti-BIRC5 Polyclonal Antibody
Brand: abinScience
SKU: HT337014
Price: 96 USD
Availability: InStock

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개요
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SDS

개요

카탈로그 번호

HT337014

설명

Anti-BIRC5 Polyclonal Antibody (HT337014) is a rabbit polyclonal antibody detecting BIRC5 in ELISA, IHC, WB. Suitable for Human, Dog, Cat, Bovine, and Cavia porcellus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human BIRC5 (Met1-Asp142).

타겟

BIRC5, IAP4, Apoptosis inhibitor survivin, Apoptosis inhibitor 4, API4, Baculoviral IAP repeat-containing protein 5

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O15392

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Baculoviral IAP repeat-containing protein 5 (BIRC5) is a ~16 kDa protein. Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.

1. Habtemichael, N. et al. (2010) Molecular and cellular neurosciences 45, 297-305. PMID: 20627126

2. Knauer, SK. et al. (2010) Cell death & disease 1, e51. PMID: 21364656

3. Liu, Y. et al. (2015) The Journal of biological chemistry 290, 11843-52. PMID: 25778398

4. Kamran, M. et al. (2017) Oncogenesis 6, e298. PMID: 28218735

5. Li, F. et al. (1998) Nature 396, 580-4. PMID: 9859993

6. Vong, QP. et al. (2005) Science (New York, N.Y.) 310, 1499-504. PMID: 16322459

7. Wang, H. et al. (2010) The Journal of biological chemistry 285, 36129-37. PMID: 20826784

8. Yamagishi, Y. et al. (2010) Science (New York, N.Y.) 330, 239-43. PMID: 20929775

9. Xia, F. et al. (2008) Molecular and cellular biology 28, 5299-311. PMID: 18591255

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-BIRC5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-BIRC5 Polyclonal Antibody (HT337014)

개요

이미지

참고 문헌

데이터시트

SDS

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