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| 카탈로그 번호 | HB360014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-BLOC1S2 Polyclonal Antibody (HB360014) is a rabbit polyclonal antibody detecting Biogenesis of lysosome-related organelles complex 1 subunit 2; BLOC-1 subunit 2; Centrosome-associated protein; BLOC1S2; BLOS2; CEAP in ELISA, IHC, WB. Suitable for Human, Rat, and Mouse.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human BLOC1S2 (Glu34-Arg142). | ||||||||
| 타겟 | Biogenesis of lysosome-related organelles complex 1 subunit 2; BLOC-1 subunit 2; Centrosome-associated protein; BLOC1S2; BLOS2; CEAP | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q6QNY1, Q32WR5, Q9CWG9 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) is a ~15 kDa protein. Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. 1. Starcevic, M. et al. (2004) The Journal of biological chemistry 279, 28393-401. PMID: 15102850 2. Setty, SR. et al. (2007) Molecular biology of the cell 18, 768-80. PMID: 17182842 3. Pu, J. et al. (2015) Developmental cell 33, 176-88. PMID: 25898167 4. Wang, Z. et al. (2004) Journal of molecular biology 343, 71-82. PMID: 15381421 | ||||||||
| 참고사항 | For research use only |
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