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| 카탈로그 번호 | HB664014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-BMP7 Polyclonal Antibody (HB664014) is a rabbit polyclonal antibody detecting BMP7 in ELISA, IHC, WB. Suitable for Human, Mouse, and Dog.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human BMP7 (Asp30-His431). | ||||||||
| 타겟 | Bone morphogenetic protein 7, Eptotermin alfa, OP-1, OP1, BMP-7, Osteogenic protein 1, BMP7 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P18075 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Bone morphogenetic protein 7 (BMP7) is a ~49 kDa protein. Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor. 1. Perron, JC. et al. (2019) Biology open 8. PMID: 31208997 2. Greenwald, J. et al. (2003) Molecular cell 11, 605-17. PMID: 12667445 3. Macías-Silva, M. et al. (1998) The Journal of biological chemistry 273, 25628-36. PMID: 9748228 4. Groppe, J. et al. (2002) Nature 420, 636-42. PMID: 12478285 5. Brunmeir, R. et al. (2016) PLoS genetics 12, e1006474. PMID: 27923061 6. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509 | ||||||||
| 참고사항 | For research use only. |
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