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| 카탈로그 번호 | BY485014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Bovine ISG15 Polyclonal Antibody (BY485014) is a rabbit polyclonal antibody detecting ISG15 in ELISA, IHC, WB. Suitable for Bovine.
Highlights
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| 종 반응성 | Bovine | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Bovine ISG15 (Met1-Gly154). | ||||||||
| 타겟 | Interferon-induced 17 kDa protein, G1P2, hUCRP, Ubiquitin-like protein ISG15, IP17, UCRP, ISG15, Ubiquitin cross-reactive protein, Interferon-induced 15 kDa protein, | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O02741 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ubiquitin-like protein ISG15 is a ~17 kDa protein. Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated-killer (LAK) activity, induce dendritic cell maturation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity. The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL. 1. Johnson, GA. et al. (1998) Biology of reproduction 58, 898-904. PMID: 9546718 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-ISG15 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
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