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| 카탈로그 번호 | HA831014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-BRDT Polyclonal Antibody (HA831014) is a rabbit polyclonal antibody detecting Bromodomain testis-specific protein; Cancer/testis antigen 9; CT9; RING3-like protein; BRDT in ELISA, IHC, WB. Suitable for Human, Rat, and Mouse.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human BRDT (Val269-Pro377). | ||||||||
| 타겟 | Bromodomain testis-specific protein; Cancer/testis antigen 9; CT9; RING3-like protein; BRDT | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q58F21, D4A7T3, Q91Y44 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Bromodomain testis-specific protein (BRDT) is a ~107 kDa protein. Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. 1. Filippakopoulos, P. et al. (2012) Cell 149, 214-31. PMID: 22464331 2. Matzuk, MM. et al. (2012) Cell 150, 673-84. PMID: 22901802 | ||||||||
| 참고사항 | For research use only |
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