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| 카탈로그 번호 | HB822023 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | IHC, WB | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | L112/26 | ||||
| 타겟 | CNR1, CB1, CANN6, CB-R, CNR, Cannabinoid receptor 1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P21554,P47746,P20272 | ||||
| RRID | Anti-Cannabinoid receptor 1 Antibody (L112/26) (abinScience Cat# HB822023, RRID:AB_3728155) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Cannabinoid receptor 1 (CNR1/CB1) is a ~52 kDa protein. G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. 1. Ryberg, E. et al. (2005) FEBS letters 579, 259-64. PMID: 15620723 2. Hua, T. et al. (2016) Cell 167, 750-762.e14. PMID: 27768894 3. Shao, Z. et al. (2016) Nature 540, 602-606. PMID: 27851727 4. Yang, X. et al. (2022) Nature chemical biology 18, 831-840. PMID: 35637350 5. Gérard, CM. et al. (1991) The Biochemical journal 279 ( Pt 1), 129-34. PMID: 1718258 6. Oddi, S. et al. (2012) British journal of pharmacology 165, 2635-51. PMID: 21895628 7. Niehaus, JL. et al. (2007) Molecular pharmacology 72, 1557-66. PMID: 17895407 8. Jourdan, T. et al. (2013) Nature medicine 19, 1132-40. PMID: 23955712 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Cannabinoid receptor 1 Antibody (L112/26)
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