Anti-CASP7 Polyclonal Antibody (HX967014)

Name: Anti-CASP7 Polyclonal Antibody
Brand: abinScience
SKU: HX967014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HX967014

설명

Anti-CASP7 Polyclonal Antibody (HX967014) is a rabbit polyclonal antibody detecting CASP7 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CASP7 (Ala24-Asp198).

타겟

CASP7, ICE-LAP3, CASP-7, MCH3, Caspase-7, CMH-1, ICE-like apoptotic protease 3, Apoptotic protease Mch-3

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P55210

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Caspase-7 (CASP7) is a ~34 kDa protein. Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins. Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences. Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7. Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1. Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins.

1. Chai, J. et al. (2001) Cell 104, 769-80. PMID: 11257230

2. Huang, Y. et al. (2001) Cell 104, 781-90. PMID: 11257231

3. Chai, J. et al. (2001) Cell 107, 399-407. PMID: 11701129

4. Hardy, JA. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 12461-6. PMID: 15314233

5. Denault, JB. et al. (2006) Molecular cell 23, 523-33. PMID: 16916640

6. Young, JE. et al. (2007) The Journal of biological chemistry 282, 30150-60. PMID: 17646170

7. Walsh, JG. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 12815-9. PMID: 18723680

8. Hardy, JA. et al. (2009) The Journal of biological chemistry 284, 26063-9. PMID: 19581639

9. Fernandes-Alnemri, T. et al. (1995) Cancer research 55, 6045-52. PMID: 8521391

10. Lippke, JA. et al. (1996) The Journal of biological chemistry 271, 1825-8. PMID: 8567622

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-CASP7 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-CASP7 Polyclonal Antibody (HX967014)

개요

이미지

참고 문헌

데이터시트

SDS