Anti-CBR1 Polyclonal Antibody (HB037014)

Name: Anti-CBR1 Polyclonal Antibody
Brand: abinScience
SKU: HB037014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HB037014

설명

Anti-CBR1 Polyclonal Antibody (HB037014) is a rabbit polyclonal antibody detecting CBR1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CBR1 (Met1-Trp277).

타겟

CBR1, CRN, Prostaglandin 9-ketoreductase, Carbonyl reductase [NADPH] 1, Short chain dehydrogenase/reductase family 21C member 1, PG-9-KR, Prostaglandin-E(2) 9-reductase, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], NADPH-dependent carbonyl reductase 1, CBR, 20-beta-hydroxysteroid dehydrogenase, SDR21C1

정제

Purified by antigen affinity column.

등록번호

P16152

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Carbonyl reductase [NADPH] 1 (CBR1) is a ~30 kDa protein. NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates.

1. Tanaka, M. et al. (2005) PLoS biology 3, e128. PMID: 15799708

2. Gonzalez-Covarrubias, V. et al. (2007) Drug metabolism and disposition: the biological fate of chemicals 35, 973-80. PMID: 17344335

3. Bateman, R. et al. (2007) Organic & biomolecular chemistry 5, 3363-7. PMID: 17912391

4. Gonzalez-Covarrubias, V. et al. (2008) Pharmaceutical research 25, 1730-4. PMID: 18449627

5. Bateman, RL. et al. (2008) The Journal of biological chemistry 283, 35756-62. PMID: 18826943

6. Forrest, GL. et al. (1991) Molecular pharmacology 40, 502-7. PMID: 1921984

7. Wermuth, B. (1981) The Journal of biological chemistry 256, 1206-13. PMID: 7005231

8. Morgan, RA. et al. (2017) Scientific reports 7, 10633. PMID: 28878267

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-CBR1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-CBR1 Polyclonal Antibody (HB037014)

개요

이미지

참고 문헌

데이터시트

SDS