Anti-M-CSF R/CD115 Polyclonal Antibody (HY035014)

Name: Anti-M-CSF R/CD115 Polyclonal Antibody
Brand: abinScience
SKU: HY035014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HY035014

설명

Anti-CD115/CSF1R Polyclonal Antibody (HY035014) is a rabbit polyclonal antibody detecting CD115 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CD115/CSF1R (Ile20-Glu512).

타겟

CD115, CSF-1 receptor, CSF1R, M-CSF-R, CSF-1-R, Proto-oncogene c-Fms, Macrophage colony-stimulating factor 1 receptor, CSF-1R, FMS

정제

Purified by antigen affinity column.

등록번호

P07333

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Macrophage colony-stimulating factor 1 receptor (CD115/CSF1R) is a ~107 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion.

1. Wei, S. et al. (2010) Journal of leukocyte biology 88, 495-505. PMID: 20504948

2. Guo, L. et al. (2019) American journal of human genetics 104, 925-935. PMID: 30982609

3. Oosterhof, N. et al. (2019) American journal of human genetics 104, 936-947. PMID: 30982608

참고사항

For research use only.

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