Anti-Human ICOS Polyclonal Antibody (HV702014)

Name: Anti-Human ICOS Polyclonal Antibody
Brand: abinScience
SKU: HV702014
Price: 168 USD
Availability: InStock

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개요

카탈로그 번호

HV702014

설명

Anti-CD278/ICOS Polyclonal Antibody (HV702014) is a rabbit polyclonal antibody detecting CD278 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CD278/ICOS (Glu21-Lys140).

타겟

CD278, ICOS, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, AILIM

정제

Purified by antigen affinity column.

등록번호

Q9Y6W8

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Inducible T-cell costimulator (CD278/ICOS) is a ~22 kDa protein. Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux.

1. Hutloff, A. et al. (1999) Nature 397, 263-6. PMID: 9930702

2. Rujas, E. et al. (2020) Nature communications 11, 5066. PMID: 33033255

3. Pedros, C. et al. (2016) Nature immunology 17, 825-33. PMID: 27135603

4. Wan, Z. et al. (2020) Cellular & molecular immunology 17, 143-152. PMID: 30523347

참고사항

For research use only.

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