Anti-CD284/TLR4 Polyclonal Antibody (HT205014)

Name: Anti-CD284/TLR4 Polyclonal Antibody
Brand: abinScience
SKU: HT205014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HT205014

설명

Anti-CD284/TLR4 Polyclonal Antibody (HT205014) is a rabbit polyclonal antibody detecting CD284 in ELISA, IHC, WB. Suitable for Human, Pan paniscus, Papio anubis, and Pongo pygmaeus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CD284/TLR4 (Glu24-Lys631).

타겟

Toll-like receptor 4, TLR4, CD284, hToll

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O00206

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Toll-like receptor 4 (CD284/TLR4) is a ~95 kDa protein. Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production.

1. Arbour, NC. et al. (2000) Nature genetics 25, 187-91. PMID: 10835634

2. Bulut, Y. et al. (2005) The Journal of biological chemistry 280, 20961-7. PMID: 15809303

3. Jung, SB. et al. (2006) Infection and immunity 74, 2686-96. PMID: 16622205

4. Georgel, P. et al. (2007) Virology 362, 304-13. PMID: 17292937

5. Kim, F. et al. (2007) Circulation research 100, 1589-96. PMID: 17478729

6. Stewart, CR. et al. (2010) Nature immunology 11, 155-61. PMID: 20037584

7. Schmidt, M. et al. (2010) Nature immunology 11, 814-9. PMID: 20711192

8. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187

9. Tatematsu, M. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 3865-76. PMID: 27022195

10. Xiahou, Z. et al. (2017) Nature communications 8, 950. PMID: 29038465

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-CD284/TLR4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-CD284/TLR4 Polyclonal Antibody (HT205014)

개요

이미지

참고 문헌

데이터시트

SDS

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