Anti-Human CLEC10A/CD301 Polyclonal Antibody (HV834014)

Name: Anti-Human CLEC10A/CD301 Polyclonal Antibody
Brand: abinScience
SKU: HV834014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HV834014

설명

Anti-CD301/CLEC10A Polyclonal Antibody (HV834014) is a rabbit polyclonal antibody detecting CLEC10A in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CD301/CLEC10A (Thr71-Met239).

타겟

CD301, Macrophage lectin 2, C-type lectin domain family 10 member A, CLECSF13, C-type lectin superfamily member 14, CLEC10A, CLECSF14, HML

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

Q8IUN9

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

C-type lectin domain family 10 member A (CD301/CLEC10A) is a ~35 kDa protein. C-type lectin receptor involved in recognition of N-acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs). Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5 and 6 glycans, and GM2 and GD2 gangliosides. Acts as a signaling receptor at the interface of APC-T cell interactions. On immature dendritic cells, recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and downregulates PTRPN/CD45 phosphatase activity with an impact on T cell activation threshold, cytokine production and proliferation. Modulates dendritic cell maturation toward a tolerogenic phenotype leading to generation of regulatory CD4-positive T cell subset with immune suppressive functions.

1. van Vliet, SJ. et al. (2005) International immunology 17, 661-9. PMID: 15802303

2. van Vliet, SJ. et al. (2006) Nature immunology 7, 1200-8. PMID: 16998493

3. van Vliet, SJ. et al. (2007) European journal of immunology 37, 2075-81. PMID: 17616966

4. Li, D. et al. (2012) The Journal of experimental medicine 209, 109-21. PMID: 22213806

5. Gabba, A. et al. (2021) Biochemistry 60, 1327-1336. PMID: 33724805

6. Suzuki, N. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 156, 128-35. PMID: 8598452

7. Mortezai, N. et al. (2013) Glycobiology 23, 844-52. PMID: 23507963

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human CLEC10A/CD301 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human CLEC10A/CD301 Polyclonal Antibody (HV834014)

개요

이미지

참고 문헌

데이터시트

SDS