Anti-Human TREM-1 Polyclonal Antibody (HV219014)

Name: Anti-Human TREM-1 Polyclonal Antibody
Brand: abinScience
SKU: HV219014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HV219014

설명

Anti-CD354/TREM1 Polyclonal Antibody (HV219014) is a rabbit polyclonal antibody detecting TREM1 in ELISA, IHC, WB. Suitable for Human and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CD354/TREM1 (Ala21-Asn205).

타겟

TREM1, Triggering receptor expressed on monocytes 1, Triggering receptor expressed on myeloid cells 1, TREM-1, CD354

정제

Purified by antigen affinity column.

등록번호

Q9NP99

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Triggering receptor expressed on myeloid cells 1 (CD354/TREM1) is a ~26 kDa protein. Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis.

1. Bouchon, A. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4991-5. PMID: 10799849

2. Arts, RJ. et al. (2011) European cytokine network 22, 11-4. PMID: 21393102

3. El Mezayen, R. et al. (2007) Immunology letters 111, 36-44. PMID: 17568691

4. Read, CB. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 1417-21. PMID: 25595774

5. Carrasco, K. et al. (2019) Cellular & molecular immunology 16, 460-472. PMID: 29568119

6. Radaev, S. et al. (2003) Structure (London, England : 1993) 11, 1527-35. PMID: 14656437

7. Ormsby, T. et al. (2011) Blood 118, 936-45. PMID: 21659545

8. Fortin, CF. et al. (2007) International immunology 19, 41-50. PMID: 17098818

9. Bouchon, A. et al. (2001) Nature 410, 1103-7. PMID: 11323674

참고사항

For research use only.

이미지

참고 문헌

SHAP-interpretable machine learning integrating exposures and multi-omics reveals immune alterations and biomarkers in COPD–lung cancer comorbidity

데이터시트

Anti-Human TREM-1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human TREM-1 Polyclonal Antibody (HV219014)

개요

이미지

참고 문헌

데이터시트

SDS

빠른 접근

문의하기