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| 카탈로그 번호 | HY215014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-CDK4 Polyclonal Antibody (HY215014) is a rabbit polyclonal antibody detecting CDK4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Ovis aries.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human CDK4 (Met1-Glu303). | ||||||||
| 타겟 | Cell division protein kinase 4, PSK-J3, Cyclin-dependent kinase 4, CDK4 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P11802 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Cyclin-dependent kinase 4 (CDK4) is a ~33 kDa protein. Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. | ||||||||
| 참고 문헌 | Circular RNA CLASP1 modulates the GLI1/SNAIL axis and enhances macrophage polarization in breast cancer.[HY215014] | ||||||||
| 참고사항 | For research use only. |
Western blot analysis of CCND1 and CDK4 protein levels in MDA-MB-231 and MCF-7 cells transfected with sh-circCLASP1 or sh-scramble.
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