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| 카탈로그 번호 | ZB997014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Chicken IL10 Polyclonal Antibody (ZB997014) is a rabbit polyclonal antibody detecting IL10 in ELISA, IHC, WB.
Highlights
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| 종 반응성 | Chicken | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Chicken IL10 (Leu22-Arg174). | ||||||||
| 테스트된 응용 분야 | WB | ||||||||
| 타겟 | CSIF, Cytokine synthesis inhibitory factor, IL-10, IL10, Interleukin-10 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 순도 | >90% as determined by SDS-PAGE. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q6A2H4 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 대체 이름 | Q6A2H4 | ||||||||
| 배경 | Interleukin-10 (IL10) is a ~20 kDa protein. Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. | ||||||||
| 참고사항 | For research use only |
Western blot analysis was performed using anti-IL10 polyclonal antibody at 1ug/mL on various samples.
Lane 1: RAW264.7 cell lysate
Lane 2: THP-1 cell lysate
Lane 3: Mouse spleen lysate
Lane 4: Mouse thymus lysate
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