Anti-CHRNA4 Polyclonal Antibody (HW493014)

Name: Anti-CHRNA4 Polyclonal Antibody
Brand: abinScience
SKU: HW493014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HW493014

설명

Anti-CHRNA4 Polyclonal Antibody (HW493014) is a rabbit polyclonal antibody detecting CHRNA4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Chicken, and Pan troglodytes.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CHRNA4 (Asn49-Leu242).

타겟

Neuronal acetylcholine receptor subunit alpha-4, NACRA4, CHRNA4

정제

Purified by antigen affinity column.

등록번호

P43681

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) is a ~69 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system.

1. Bondarenko, V. et al. (2012) Biochimica et biophysica acta 1818, 1261-8. PMID: 22361591

2. Morales-Perez, CL. et al. (2016) Nature 538, 411-415. PMID: 27698419

3. Walsh, RM. et al. (2018) Nature 557, 261-265. PMID: 29720657

4. Mazzaferro, S. et al. (2024) British journal of pharmacology 181, 1973-1992. PMID: 38454578

5. Tumkosit, P. et al. (2006) Molecular pharmacology 70, 1358-68. PMID: 16835356

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-CHRNA4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-CHRNA4 Polyclonal Antibody (HW493014)

개요

이미지

참고 문헌

데이터시트

SDS