Anti-CLCN2 Polyclonal Antibody (HA683014)

Name: Anti-CLCN2 Polyclonal Antibody
Brand: abinScience
SKU: HA683014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HA683014

설명

Anti-CLCN2 Polyclonal Antibody (HA683014) is a rabbit polyclonal antibody detecting Chloride channel protein 2; ClC-2; CLCN2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human CLCN2 (Leu568-Gly847).

타겟

Chloride channel protein 2; ClC-2; CLCN2

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P51788, Q9R0A1, P35525

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Chloride channel protein 2 (CLCN2) is a ~98 kDa protein. Voltage-gated and osmosensitive chloride channel. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Displays inward rectification currents activated upon membrane hyperpolarization and extracellular hypotonicity. Contributes to chloride conductance involved in neuron excitability.

1. Peña-Münzenmayer, G. et al. (2005) Journal of cell science 118, 4243-52. PMID: 16155254

2. Blanz, J. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 6581-9. PMID: 17567819

3. Saint-Martin, C. et al. (2009) Human mutation 30, 397-405. PMID: 19191339

4. Stölting, G. et al. (2013) Pflugers Archiv : European journal of physiology 465, 1423-37. PMID: 23632988

5. Scholl, UI. et al. (2018) Nature genetics 50, 349-354. PMID: 29403011

6. Fernandes-Rosa, FL. et al. (2018) Nature genetics 50, 355-361. PMID: 29403012

7. Xu, P. et al. (2023) Human genetics 142, 577-593. PMID: 36964785

8. Xu, M. et al. (2024) eLife 12. PMID: 38345841

9. Jeworutzki, E. et al. (2012) Neuron 73, 951-61. PMID: 22405205

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-CLCN2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-CLCN2 Polyclonal Antibody (HA683014)

개요

이미지

참고 문헌

데이터시트

SDS