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| 카탈로그 번호 | HB593014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-CLIC3 Polyclonal Antibody (HB593014) is a rabbit polyclonal antibody detecting Chloride intracellular channel protein 3; CLIC3 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human CLIC3 (Asp45-Arg236). | ||||||||
| 타겟 | Chloride intracellular channel protein 3; CLIC3 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O95833, Q9D7P7 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Chloride intracellular channel protein 3 (CLIC3) is a ~26 kDa protein. In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding. Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control. 1. Hernandez-Fernaud, JR. et al. (2017) Nature communications 8, 14206. PMID: 28198360 2. Alghalayini, A. et al. (2023) Biomolecules 13. PMID: 37759794 | ||||||||
| 참고사항 | For research use only |
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