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| 카탈로그 번호 | JN888014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Clostridium botulinum BotA Polyclonal Antibody (JN888014) is a rabbit polyclonal antibody detecting botA. Suitable for Clostridium botulinum.
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| 종 반응성 | Clostridium botulinum | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Clostridium botulinum BotA (Met1-Glu424). | ||||||||
| 타겟 | BOTOX, BoNT/A, Bontoxilysin-A, Botulinum neurotoxin A heavy chain, Botulinum neurotoxin A light chain, Botulinum neurotoxin type A, Botulinum neurotoxin type A1, EC:3.4.24.69, HC, LC, atx, bonT, botA | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P0DPI0 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Botulinum neurotoxin type A (BotA) is a ~149 kDa protein. Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin A which has 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins of synaptic vesicles. Receptor proteins are exposed on host presynaptic cell membrane during neurotransmitter release, when the toxin heavy chain (HC) binds to them. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the HC forms pores that allows the light chain (LC) to translocate into the cytosol. 1. BURGEN, AS. et al. (1949) The Journal of physiology 109, 10-24. PMID: 15394302 2. Zhou, L. et al. (1995) Biochemistry 34, 15175-81. PMID: 7578132 3. Fischer, A. et al. (2007) The Journal of biological chemistry 282, 29604-11. PMID: 17666397 4. Fischer, A. et al. (2008) PLoS pathogens 4, e1000245. PMID: 19096517 5. Yowler, BC. et al. (2002) The Journal of biological chemistry 277, 32815-9. PMID: 12089155 6. Dong, M. et al. (2006) Science (New York, N.Y.) 312, 592-6. PMID: 16543415 7. Mahrhold, S. et al. (2006) FEBS letters 580, 2011-4. PMID: 16545378 8. Dong, M. et al. (2008) Molecular biology of the cell 19, 5226-37. PMID: 18815274 | ||||||||
| 참고사항 | For research use only |
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