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| 카탈로그 번호 | HW523014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-CPT1A Polyclonal Antibody (HW523014) is a rabbit polyclonal antibody detecting CPT1A in ELISA, IHC, WB. Suitable for Human, Mouse, and Equus caballus.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human CPT1A (Gln406-Thr745). | ||||||||
| 타겟 | CPT1, CPTI-L, Carnitine O-palmitoyltransferase I, liver isoform, CPT1A, CPT I, Carnitine palmitoyltransferase 1A, CPT1-L, Carnitine O-palmitoyltransferase 1, liver isoform | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P50416 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) is a ~88 kDa protein. Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity. Plays an important role in hepatic triglyceride metabolism. Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression. Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation. 1. Prip-Buus, C. et al. (2001) Molecular genetics and metabolism 73, 46-54. PMID: 11350182 2. Gobin, S. et al. (2003) The Journal of biological chemistry 278, 50428-34. PMID: 14517221 3. Wolfgang, MJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 7282-7. PMID: 16651524 4. IJlst, L. et al. (1998) The Journal of clinical investigation 102, 527-31. PMID: 9691089 5. Kurmi, K. et al. (2018) Cell reports 22, 1365-1373. PMID: 29425493 6. Zhang, G. et al. (2023) Molecular cell 83, 4370-4385.e9. PMID: 38016475 | ||||||||
| 참고사항 | For research use only. |
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