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| 카탈로그 번호 | HB380014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-CRYZ Polyclonal Antibody (HB380014) is a rabbit polyclonal antibody detecting Quinone oxidoreductase; 1.6.5.5; NADPH:quinone reductase; Zeta-crystallin; CRYZ in ELISA, IHC, WB. Suitable for Human and Bovine.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human CRYZ (Met1-Leu329). | ||||||||
| 타겟 | Quinone oxidoreductase; 1.6.5.5; NADPH:quinone reductase; Zeta-crystallin; CRYZ | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q08257, O97764 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Zeta-crystallin (CRYZ) is a ~35 kDa protein. Multifunctional crystallin endowed with unrelated mRNA stabilization and enzymatic oxidoreductase activities. Binds (AU)-rich elements (ARE) in the 3'-UTR of target mRNA to enhance their stability. Upon metabolic acidosis, stabilizes the mRNA encoding SLC12A1 a cotransporter involved in transepithelial NH4(+) reabsorption in the medullary thick ascending limb in kidney. In response to acidosis, also participates to the adaptive increase in renal ammoniagenesis by stabilizing the mRNAs of enzymes involved in glutamine catabolism. By the same mechanism, it also regulates the expression of the antiapoptotic protein BCL2. 1. Fernández, MR. et al. (2007) Cellular and molecular life sciences : CMLS 64, 1419-27. PMID: 17497241 2. Lapucci, A. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 1852-65. PMID: 20103721 | ||||||||
| 참고사항 | For research use only |
Western blot analysis was performed using anti-CRYZ polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: K562 cell lysate
Lane 3: Jurkat cell lysate
Lane 4: Raji cell lysate
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