Anti-Human CXCL10/IP-10 Polyclonal Antibody (HY524014)

Name: Anti-Human CXCL10/IP-10 Polyclonal Antibody
Brand: abinScience
SKU: HY524014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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개요

카탈로그 번호

HY524014

설명

Anti-CXCL10/IP-10 Polyclonal Antibody (HY524014) is a rabbit polyclonal antibody detecting IP-10 in ELISA, IHC, WB. Suitable for Human, Macaca mulatta, and Macaca nemestrina.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CXCL10/IP-10 (Val22-Pro98).

타겟

Gamma-IP10, C-X-C motif chemokine 10, INP10, 10 kDa interferon gamma-induced protein, Small-inducible cytokine B10, SCYB10, IP-10, CXCL10

정제

Purified by antigen affinity column.

등록번호

P02778

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

C-X-C motif chemokine 10 (CXCL10/IP-10) is a ~10 kDa protein. Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site.

1. Romagnani, P. et al. (2001) Blood 97, 601-7. PMID: 11157474

2. Sidahmed, AM. et al. (2012) Cytokine 59, 433-41. PMID: 22652417

3. Angiolillo, AL. et al. (1995) The Journal of experimental medicine 182, 155-62. PMID: 7540647

4. Smit, MJ. et al. (2003) Blood 102, 1959-65. PMID: 12750173

5. Gao, JM. et al. (2009) Acta pharmacologica Sinica 30, 193-201. PMID: 19151743

6. Cheeran, MC. et al. (2003) Journal of virology 77, 4502-15. PMID: 12663757

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human CXCL10/IP-10 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human CXCL10/IP-10 Polyclonal Antibody (HY524014)

개요

이미지

참고 문헌

데이터시트

SDS