Anti-CYP17A1 Polyclonal Antibody (HY444014)

Name: Anti-CYP17A1 Polyclonal Antibody
Brand: abinScience
SKU: HY444014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HY444014

설명

Anti-CYP17A1 Polyclonal Antibody (HY444014) is a rabbit polyclonal antibody detecting CYP17A1 in ELISA, IHC, WB. Suitable for Human, Macaca fascicularis, Macaca mulatta, Pan troglodytes, and Papio cynocephalus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CYP17A1 (Cys183-Thr508).

타겟

Steroid 17-alpha-hydroxylase/17, 20 lyase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Steroid 17-alpha-monooxygenase, 17-alpha-hydroxyprogesterone aldolase, CYP17A1, S17AH, Cytochrome P450c17, CYP17

정제

Purified by antigen affinity column.

등록번호

P05093

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione.

1. DeVore, NM. et al. (2012) Nature 482, 116-9. PMID: 22266943

2. Petrunak, EM. et al. (2014) The Journal of biological chemistry 289, 32952-64. PMID: 25301938

3. Yoshimoto, FK. et al. (2016) The Journal of biological chemistry 291, 17143-64. PMID: 27339894

4. Auchus, RJ. et al. (1998) The Journal of biological chemistry 273, 3158-65. PMID: 9452426

5. Lee, SG. et al. (2023) Journal of inorganic biochemistry 240, 112085. PMID: 36640554

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-CYP17A1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-CYP17A1 Polyclonal Antibody (HY444014)

개요

이미지

참고 문헌

데이터시트

SDS