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| 카탈로그 번호 | HT346014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-CYP26A1 Polyclonal Antibody (HT346014) is a rabbit polyclonal antibody detecting CYP26A1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human CYP26A1 (Arg73-Ile255). | ||||||||
| 타겟 | P450RAI1, Cytochrome P450 26A1, Cytochrome P450RAI, hP450RAI, CYP26A1, Cytochrome P450 retinoic acid-inactivating 1, Retinoic acid-metabolizing cytochrome, CYP26, Retinoic acid 4-hydroxylase | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O43174 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Cytochrome P450 26A1 (CYP26A1) is a ~56 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. 1. Topletz, AR. et al. (2012) Biochemical pharmacology 83, 149-63. PMID: 22020119 2. White, JA. et al. (1997) The Journal of biological chemistry 272, 18538-41. PMID: 9228017 3. Sonneveld, E. et al. (1998) Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 9, 629-37. PMID: 9716180 4. Foti, RS. et al. (2016) The Journal of pharmacology and experimental therapeutics 357, 281-92. PMID: 26937021 | ||||||||
| 참고사항 | For research use only. |
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