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| 카탈로그 번호 | HV995014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-CYP26B1 Polyclonal Antibody (HV995014) is a rabbit polyclonal antibody detecting CYP26B1. Suitable for Human, Mouse, and Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human CYP26B1 (Thr97-Val512). | ||||||||
| 타겟 | CYP26A2, CYP26B1, Cytochrome P450 26A2, Cytochrome P450 26B1, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450RAI-2, EC:1.14.13.-, P450RAI2, Retinoic acid-metabolizing cytochrome | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 관찰된 분자량 | 53 kDa | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9NR63 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||||||
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. | ||||||||
| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Cytochrome P450 26B1 is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination. Involved in the convertion of atRA to all-trans-4-oxo-RA. 1. White, JA. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 6403-8. PMID: 10823918 2. Topletz, AR. et al. (2012) Biochemical pharmacology 83, 149-63. PMID: 22020119 3. Laue, K. et al. (2011) American journal of human genetics 89, 595-606. PMID: 22019272 | ||||||||
| 참고사항 | For research use only |
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