Anti-DLD Polyclonal Antibody (HY347014)

Name: Anti-DLD Polyclonal Antibody
Brand: abinScience
SKU: HY347014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HY347014

설명

Anti-DLD Polyclonal Antibody (HY347014) is a rabbit polyclonal antibody detecting DLD in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human DLD (Lys283-His487).

타겟

Glycine cleavage system L protein, Dihydrolipoamide dehydrogenase, GCSL, DLD, PHE3, Dihydrolipoyl dehydrogenase, mitochondrial, LAD

정제

Purified by antigen affinity column.

등록번호

P09622

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Dihydrolipoyl dehydrogenase, mitochondrial (DLD) is a ~54 kDa protein. Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.

1. Odièvre, MH. et al. (2005) Human mutation 25, 323-4. PMID: 15712224

2. Brautigam, CA. et al. (2006) Structure (London, England : 1993) 14, 611-21. PMID: 16442803

3. Cameron, JM. et al. (2006) American journal of medical genetics. Part A 140, 1542-52. PMID: 16770810

4. Babady, NE. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 6158-63. PMID: 17404228

5. Patel, MS. et al. (2009) Journal of molecular catalysis. B, Enzymatic 61, 2-6. PMID: 20160912

6. Park, YH. et al. (2010) Biochemical and biophysical research communications 395, 416-9. PMID: 20385101

7. Wang, Y. et al. (2017) Nature 552, 273-277. PMID: 29211711

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-DLD Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-DLD Polyclonal Antibody (HY347014)

개요

이미지

참고 문헌

데이터시트

SDS