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| 카탈로그 번호 | HB541014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-DNASE1L3 Polyclonal Antibody (HB541014) is a rabbit polyclonal antibody detecting Deoxyribonuclease gamma; DNase gamma; 3.1.21.-; DNase I homolog protein DHP2; Deoxyribonuclease I-like 3; DNase I-like 3; Liver and spleen DNase; LS-DNase; LSD; DNASE1L3; DHP2; DNAS1L3 in ELISA, IHC, WB. Suitable for Human and Rat.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human DNASE1L3 (Met21-Ser305). | ||||||||
| 타겟 | Deoxyribonuclease gamma; DNase gamma; 3.1.21.-; DNase I homolog protein DHP2; Deoxyribonuclease I-like 3; DNase I-like 3; Liver and spleen DNase; LS-DNase; LSD; DNASE1L3; DHP2; DNAS1L3 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q13609, O89107 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Deoxyribonuclease gamma (DNASE1L3) is a ~35 kDa protein. Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. 1. Yakovlev, AG. et al. (2000) The Journal of biological chemistry 275, 21302-8. PMID: 10807908 2. Shiokawa, D. et al. (1998) Apoptosis : an international journal on programmed cell death 3, 89-95. PMID: 14646506 3. Sisirak, V. et al. (2016) Cell 166, 88-101. PMID: 27293190 4. Zeng, Z. et al. (1997) Biochemical and biophysical research communications 231, 499-504. PMID: 9070308 5. Baron, WF. et al. (1998) Gene 215, 291-301. PMID: 9714828 6. Errami, Y. et al. (2013) The Journal of biological chemistry 288, 3460-8. PMID: 23229555 7. Mizuta, R. et al. (2013) PloS one 8, e80223. PMID: 24312463 | ||||||||
| 참고사항 | For research use only |
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