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| 카탈로그 번호 | HF514014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-EFEMP2 Polyclonal Antibody (HF514014) is a rabbit polyclonal antibody detecting EFEMP2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Cricetulus griseus.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human EFEMP2 (Ser26-Phe443). | ||||||||
| 타겟 | EGF-containing fibulin-like extracellular matrix protein 2, Protein UPH1, Fibulin-4, FBLN4, EFEMP2, FIBL-4 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O95967 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) is a ~49 kDa protein. Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling. 1. Sasaki, T. et al. (2016) Matrix biology : journal of the International Society for Matrix Biology 56, 132-149. PMID: 27339457 2. Cirulis, JT. et al. (2008) Biochemistry 47, 12601-13. PMID: 18973305 3. Choudhury, R. et al. (2009) The Journal of biological chemistry 284, 24553-67. PMID: 19570982 4. Djokic, J. et al. (2013) The Journal of biological chemistry 288, 22821-35. PMID: 23782690 | ||||||||
| 참고사항 | For research use only. |
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