Anti-EP300 Polyclonal Antibody (HC510014)

Name: Anti-EP300 Polyclonal Antibody
Brand: abinScience
SKU: HC510014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HC510014

설명

Anti-EP300 Polyclonal Antibody (HC510014) is a rabbit polyclonal antibody detecting EP300 in ELISA, IHC, WB. Suitable for Mouse and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human EP300 (His2283-His2414).

타겟

Histone crotonyltransferase p300, Protein lactyltransferas p300, Protein propionyltransferase p300, Histone acetyltransferase p300, Protein 2-hydroxyisobutyryltransferase p300, EP300, p300 HAT, Histone butyryltransferase p300, P300, E1A-associated protein p300

정제

Purified by antigen affinity column.

등록번호

Q09472

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Histone acetyltransferase p300 (EP300) is a ~264 kDa protein. Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively).

1. Tropberger, P. et al. (2013) Cell 152, 859-72. PMID: 23415232

2. Delvecchio, M. et al. (2013) Nature structural & molecular biology 20, 1040-6. PMID: 23934153

3. Tian, Y. et al. (2025) Nature 641, 779-787. PMID: 40240600

4. Ogryzko, VV. et al. (1996) Cell 87, 953-9. PMID: 8945521

5. Jin, Q. et al. (2011) The EMBO journal 30, 249-62. PMID: 21131905

6. Hatzi, K. et al. (2013) Cell reports 4, 578-88. PMID: 23911289

8. Iioka, T. et al. (2003) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 18, 1419-29. PMID: 12929931

9. Yuan, ZL. et al. (2005) Science (New York, N.Y.) 307, 269-73. PMID: 15653507

10. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960

참고사항

For research use only.

이미지

참고 문헌

데이터시트