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| 카탈로그 번호 | HB046014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-EPHA1 Polyclonal Antibody (HB046014) is a rabbit polyclonal antibody detecting EPHA1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human EPHA1 (Tyr599-Gly842). | ||||||||
| 타겟 | Tyrosine-protein kinase receptor EPH, EPHT1, Erythropoietin-producing hepatoma receptor, hEpha1, EPH, EPHA1, Ephrin type-A receptor 1, EPH tyrosine kinase 1, EPH tyrosine kinase, EPHT | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P21709 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ephrin type-A receptor 1 (EPHA1) is a ~108 kDa protein. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. | ||||||||
| 참고사항 | For research use only. |
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