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| 카탈로그 번호 | HV250014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human FMO2 (Gly295-Asn469). | ||||||||
| 타겟 | FMO 1B1, FMO 2, Dimethylaniline monooxygenase [N-oxide-forming] 2, Pulmonary flavin-containing monooxygenase 2, Dimethylaniline oxidase 2, FMO2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q99518 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Flavin-containing monooxygenase 2 (FMO2) is a ~60 kDa protein. Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation. Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid. In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate. Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton. 1. Henderson, MC. et al. (2004) Chemical research in toxicology 17, 633-40. PMID: 15144220 2. Henderson, MC. et al. (2004) Biochemical pharmacology 68, 959-67. PMID: 15294458 3. Henderson, MC. et al. (2008) Toxicology and applied pharmacology 233, 420-7. PMID: 18930751 4. Francois, AA. et al. (2009) Drug metabolism and disposition: the biological fate of chemicals 37, 178-86. PMID: 18948378 5. Dolphin, CT. et al. (1998) The Journal of biological chemistry 273, 30599-607. PMID: 9804831 | ||||||||
| 참고사항 | For research use only. |
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