

| 카탈로그 번호 | HV281014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-FN3K Polyclonal Antibody (HV281014) is a rabbit polyclonal antibody detecting FN3K in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human FN3K (Met1-Lys309). | ||||||||
| 타겟 | Protein-ribulosamine 3-kinase FN3K, Protein-psicosamine 3-kinase FN3K, FN3K, Fructosamine-3-kinase | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9H479 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Fructosamine-3-kinase (FN3K) is a ~35 kDa protein. Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines. 1. Delpierre, G. et al. (2000) Diabetes 49, 1627-34. PMID: 11016445 2. Szwergold, BS. et al. (2001) Diabetes 50, 2139-47. PMID: 11522682 3. Delpierre, G. et al. (2002) The Biochemical journal 365, 801-8. PMID: 11975663 4. Collard, F. et al. (2003) Diabetes 52, 2888-95. PMID: 14633848 | ||||||||
| 참고사항 | For research use only. |
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