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| 카탈로그 번호 | HB309014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-FOXK1 Polyclonal Antibody (HB309014) is a rabbit polyclonal antibody detecting Forkhead box protein K1; Myocyte nuclear factor; MNF; FOXK1; MNF in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human FOXK1 (Ala86-Arg395). | ||||||||
| 타겟 | Forkhead box protein K1; Myocyte nuclear factor; MNF; FOXK1; MNF | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P85037, P42128 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Forkhead box protein K1 (FOXK1) is a ~75 kDa protein. Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4. Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate. 1. Freddie, CT. et al. (2007) Nucleic acids research 35, 5203-12. PMID: 17670796 2. Wang, W. et al. (2015) Developmental cell 32, 707-18. PMID: 25805136 3. Panda, D. et al. (2015) mBio 6. PMID: 25852164 4. Baymaz, HI. et al. (2014) Proteomics 14, 2179-89. PMID: 24634419 5. Campagne, A. et al. (2019) Nature communications 10, 348. PMID: 30664650 6. Zhang, HL. et al. (2025) Nature chemical biology 21, 1531-1543. PMID: 40246981 | ||||||||
| 참고사항 | For research use only |
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