Anti-FPR1 Polyclonal Antibody (HB008014)

Name: Anti-FPR1 Polyclonal Antibody
Brand: abinScience
SKU: HB008014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HB008014

설명

Anti-FPR1 Polyclonal Antibody (HB008014) is a rabbit polyclonal antibody detecting FPR1 in ELISA, IHC, WB. Suitable for Human, Pan troglodytes, and Pongo pygmaeus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human FPR1 (Arg163-Val242).

타겟

fMet-Leu-Phe receptor, fMLP receptor, N-formyl peptide receptor, FPR, FPR1, N-formylpeptide chemoattractant receptor

정제

Purified by antigen affinity column.

등록번호

P21462

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

N-formyl peptide receptor 1 (FPR1) is a ~38 kDa protein. Pattern recognition G-protein coupled receptor (PRR/GPCR) involved in innate recognition of N-formyl-methionyl peptides derived from invading microbes and host mitochondria as pathogen- and damage-associated molecular patterns (PAMPs and DAMPs). Functions as a sensor of PAMPs and DAMPs released upon microbial infection or tissue damage, triggering immune cell activation and chemotaxis to eliminate pathogens and restore tissue homeostasis. Peptide binding leads to conformational changes coupled to heterotrimeric G(i) protein signaling. Upon GDP to GTP conversion, G(i)-alpha subunit dissociates from G-beta and G-gamma subunits. Free G(i)-alpha subunit inhibits cyclic adenylate cyclase and cAMP synthesis whereas the G-beta and G-gamma dimer activates downstream phospholipase C-beta and phosphoinositide 3-kinase signaling cascades leading to Ca(2+) influx.

1. Cooray, SN. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 18232-7. PMID: 24108355

2. Bufe, B. et al. (2015) The Journal of biological chemistry 290, 7369-87. PMID: 25605714

3. Zhuang, Y. et al. (2022) Nature communications 13, 1054. PMID: 35217703

4. Chen, G. et al. (2022) Nature communications 13, 5232. PMID: 36064945

5. Maestes, DC. et al. (1999) The Journal of biological chemistry 274, 29791-5. PMID: 10514456

6. Postma, B. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 6994-7001. PMID: 15153520

7. Murphy, PM. et al. (1991) The Journal of biological chemistry 266, 12560-7. PMID: 1712023

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-FPR1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-FPR1 Polyclonal Antibody (HB008014)

개요

이미지

참고 문헌

데이터시트

SDS