中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HB780014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-GABRA5 Polyclonal Antibody (HB780014) is a rabbit polyclonal antibody detecting Gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor subunit alpha-5; GABRA5 in ELISA, IHC, WB. Suitable for Human, Rat, Mouse, and Bovine.
Highlights
|
||||||||
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human GABRA5 (Gln32-Tyr259). | ||||||||
| 타겟 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor subunit alpha-5; GABRA5 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P31644, P19969, Q8BHJ7, Q08E50 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) is a ~52 kDa protein. Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus. Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes. 1. Caraiscos, VB. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 3662-7. PMID: 14993607 2. Butler, KM. et al. (2018) Brain : a journal of neurology 141, 2392-2405. PMID: 29961870 3. Liu, S. et al. (2018) Cell research 28, 958-961. PMID: 30140029 4. Hernandez, CC. et al. (2019) Brain : a journal of neurology 142, 1938-1954. PMID: 31056671 | ||||||||
| 참고사항 | For research use only. |
문의하기
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
