Anti-GDF5 Polyclonal Antibody (HW374014)

Name: Anti-GDF5 Polyclonal Antibody
Brand: abinScience
SKU: HW374014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HW374014

설명

Anti-GDF5 Polyclonal Antibody (HW374014) is a rabbit polyclonal antibody detecting GDF5 in ELISA, IHC, WB. Suitable for Mouse and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human GDF5 (Ala382-Arg501).

타겟

Growth/differentiation factor 5, BMP14, BMP-14, Radotermin, GDF-5, Bone morphogenetic protein 14, GDF5, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, CDMP1, Cartilage-derived morphogenetic protein 1, LPS-associated protein 4

정제

Purified by antigen affinity column.

등록번호

P43026

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Growth/differentiation factor 5 (GDF5) is a ~55 kDa protein. Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation.

1. Bai, X. et al. (2004) Biochemical and biophysical research communications 325, 453-60. PMID: 15530414

2. Schwaerzer, GK. et al. (2012) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 27, 429-42. PMID: 21976273

3. Degenkolbe, E. et al. (2013) PLoS genetics 9, e1003846. PMID: 24098149

4. Stange, K. et al. (2014) Journal of molecular biology 426, 3221-3231. PMID: 25092592

5. Triantafilou, K. et al. (2001) Nature immunology 2, 338-45. PMID: 11276205

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-GDF5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-GDF5 Polyclonal Antibody (HW374014)

개요

이미지

참고 문헌

데이터시트

SDS

빠른 접근

문의하기