Anti-GNAI2 Polyclonal Antibody (HB595014)

Name: Anti-GNAI2 Polyclonal Antibody
Brand: abinScience
SKU: HB595014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HB595014

설명

Anti-GNAI2 Polyclonal Antibody (HB595014) is a rabbit polyclonal antibody detecting Guanine nucleotide-binding protein G(i) subunit alpha-2; Adenylate cyclase-inhibiting G alpha protein; GNAI2; GNAI2B in ELISA, IHC, WB. Suitable for Human, Rat, Mouse, Dog, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human GNAI2 (Ala31-Phe355).

타겟

Guanine nucleotide-binding protein G(i) subunit alpha-2; Adenylate cyclase-inhibiting G alpha protein; GNAI2; GNAI2B

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P04899, P04897, P08752, P38400, P50147, P10824, P63096, P63097, B2RSH2, P50146, P27044, P08754

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) is a ~40 kDa protein. Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. Examples of interacting GPCRs include the adenosine A1 receptor/ADORA1, CNR1, and FPR2. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal.

1. Bai, CW. et al. (2024) Theranostics 14, 2190-2209. PMID: 38505600

2. Draper-Joyce, CJ. et al. (2018) Nature 558, 559-563. PMID: 29925945

3. Yang, X. et al. (2022) Nature chemical biology 18, 831-840. PMID: 35637350

4. Zhu, Y. et al. (2022) Nature communications 13, 1775. PMID: 35365641

5. Komatsuzaki, K. et al. (2002) Biochemical and biophysical research communications 297, 898-905. PMID: 12359238

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-GNAI2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-GNAI2 Polyclonal Antibody (HB595014)

개요

이미지

참고 문헌

데이터시트

SDS