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| 카탈로그 번호 | VK617024 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-gp120 Polyclonal Antibody (VK617024) is a rabbit polyclonal antibody detecting gp120 in ELISA, IHC, WB.
Highlights
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| 종 반응성 | Human immunodeficiency virus type 2 (HIV-2) | ||||
| 응용 분야 | ELISA, IHC, WB | ||||
| 숙주 종 | Rabbit | ||||
| 클론성 | Polyclonal | ||||
| 이소타입 | IgG | ||||
| 면역원 | E. coli - derived recombinant hiv-2 gp120 (Lys23-Thr501). | ||||
| 타겟 | Envelope glycoprotein gp160, Env polyprotein, Surface protein gp120, SU, Glycoprotein 120, gp120, Transmembrane protein gp41, TM, Glycoprotein 41, gp41, env | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 정제 | Purified by antigen affinity column. | ||||
| 등록번호 | P05883 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Envelope glycoprotein gp160 (gp120) is a ~98 kDa protein. The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. Since CD4 also displays a binding site for the disulfide-isomerase P4HB/PDI, a P4HB/PDI-CD4-CXCR4-gp120 complex may form. In that complex, P4HB/PDI could reach and reduce gp120 disulfide bonds, causing major conformational changes in gp120. | ||||
| 참고사항 | For research use only |
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