Anti-GPR4 Polyclonal Antibody (HA696014)

Name: Anti-GPR4 Polyclonal Antibody
Brand: abinScience
SKU: HA696014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HA696014

설명

Anti-GPR4 Polyclonal Antibody (HA696014) is a rabbit polyclonal antibody detecting G-protein coupled receptor 4; G-protein coupled receptor 6C.l; GPR6C.l; GPR4 in ELISA, IHC, WB. Suitable for Human, Bovine, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human GPR4 (Ile284-Gln362).

타겟

G-protein coupled receptor 4; G-protein coupled receptor 6C.l; GPR6C.l; GPR4

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P46093, Q1JQB3, P50132

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

G-protein coupled receptor 4 (GPR4) is a ~40 kDa protein. Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. Activated by an optimal pH of 6.8-7.2. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPR4 is mainly coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May also couple with G(i), G(q) and G(12)/G(13) G proteins.

1. Ludwig, MG. et al. (2003) Nature 425, 93-8. PMID: 12955148

2. Tobo, M. et al. (2007) Cellular signalling 19, 1745-53. PMID: 17462861

3. Rowe, JB. et al. (2021) The Journal of biological chemistry 296, 100167. PMID: 33478938

4. Howard, MK. et al. (2025) Cell 188, 671-687.e20. PMID: 39753132

5. Ma, Y. et al. (2025) Nature communications 16, 605. PMID: 39799123

6. Yue, X. et al. (2025) Cell research 35, 423-436. PMID: 40211064

7. Guo, L. et al. (2025) Molecular cell 85, 1658-1673.e7. PMID: 40215959

8. Chen, LN. et al. (2025) Molecular cell 85, 1640-1657.e8. PMID: 40215960

참고사항

For research use only

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참고 문헌

데이터시트

Anti-GPR4 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-GPR4 Polyclonal Antibody (HA696014)

개요

이미지

참고 문헌

데이터시트

SDS