中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HS932014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-GPR68 Polyclonal Antibody (HS932014) is a rabbit polyclonal antibody detecting Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor; GPR68; OGR1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
|
||||||||
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human GPR68 (Leu285-Ala365). | ||||||||
| 타겟 | Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor; GPR68; OGR1 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q15743, Q8BFQ3 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | G-protein coupled receptor 68 (GPR68) is a ~41 kDa protein. Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Acts as a key mechanosensor of fluid shear stress and membrane stretch. 1. Ludwig, MG. et al. (2003) Nature 425, 93-8. PMID: 12955148 2. Xu, J. et al. (2018) Cell 173, 762-775.e16. PMID: 29677517 3. Huang, XP. et al. (2020) Biochemistry 59, 3594-3614. PMID: 32865988 4. Rowe, JB. et al. (2021) The Journal of biological chemistry 296, 100167. PMID: 33478938 5. Howard, MK. et al. (2025) Cell 188, 671-687.e20. PMID: 39753132 6. Guo, L. et al. (2025) Molecular cell 85, 1658-1673.e7. PMID: 40215959 7. Chen, LN. et al. (2025) Molecular cell 85, 1640-1657.e8. PMID: 40215960 | ||||||||
| 참고사항 | For research use only |
문의하기
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
