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| 카탈로그 번호 | HW661014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-GRIA2 Polyclonal Antibody (HW661014) is a rabbit polyclonal antibody detecting GRIA2/GluR-2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human GRIA2 (Asn25-Ala543). | ||||||||
| 타겟 | GluR-2, AMPA-selective glutamate receptor 2, GluR-B, Glutamate receptor 2, GLUR2, GRIA2, GluA2, Glutamate receptor ionotropic, AMPA 2, GluR-K2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P42262 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Glutamate receptor 2 (GRIA2/GluR-2) is a ~98 kDa protein. Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. 1. Ward, SE. et al. (2010) Journal of medicinal chemistry 53, 5801-12. PMID: 20614889 2. Salpietro, V. et al. (2019) Nature communications 10, 3094. PMID: 31300657 3. Sun, W. et al. (1994) Neuroreport 5, 441-4. PMID: 8003671 4. Kolleker, A. et al. (2003) Neuron 40, 1199-212. PMID: 14687553 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-GRIA2 polyclonal antibody at 1μg/ml on various samples.
Lane 1: SKOV3 cell lysate
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