Anti-GRIN2A Polyclonal Antibody (HC657014)

Name: Anti-GRIN2A Polyclonal Antibody
Brand: abinScience
SKU: HC657014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HC657014

설명

Anti-GRIN2A Polyclonal Antibody (HC657014) is a rabbit polyclonal antibody detecting GRIN2A in ELISA, IHC, WB. Suitable for Human, Mouse, Pan troglodytes, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human GRIN2A (Pro23-Ala555).

타겟

N-methyl D-aspartate receptor subtype 2A, NMDAR2A, Glutamate [NMDA] receptor subunit epsilon-1, hNR2A, NR2A, Glutamate receptor ionotropic, NMDA 2A, GRIN2A, GluN2A

정제

Purified by antigen affinity column.

등록번호

Q12879

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Glutamate receptor ionotropic, NMDA 2A (GRIN2A) is a ~165 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.

1. Endele, S. et al. (2010) Nature genetics 42, 1021-6. PMID: 20890276

2. Carvill, GL. et al. (2013) Nature genetics 45, 1073-6. PMID: 23933818

3. Lemke, JR. et al. (2013) Nature genetics 45, 1067-72. PMID: 23933819

4. Lesca, G. et al. (2013) Nature genetics 45, 1061-6. PMID: 23933820

5. Yuan, H. et al. (2014) Nature communications 5, 3251. PMID: 24504326

6. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626

7. Volgraf, M. et al. (2016) Journal of medicinal chemistry 59, 2760-79. PMID: 26919761

8. Addis, L. et al. (2017) Scientific reports 7, 66. PMID: 28242877

9. Iacobucci, GJ. et al. (2022) Molecular psychiatry 27, 5113-5123. PMID: 36117210

10. Xu, Y. et al. (2024) Cellular and molecular life sciences : CMLS 81, 153. PMID: 38538865

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-GRIN2A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-GRIN2A Polyclonal Antibody (HC657014)

개요

이미지

참고 문헌

데이터시트

SDS

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