Anti-GRIN2B Polyclonal Antibody (HC330014)

Name: Anti-GRIN2B Polyclonal Antibody
Brand: abinScience
SKU: HC330014
Price: 96 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

20ug
50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HC330014

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human GRIN2B (Tyr1133-Val1484).

타겟

GluN2B, Glutamate receptor ionotropic, NMDA 2B, GRIN2B, NMDAR2B, NR2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl-D-aspartate receptor subunit 3, N-methyl D-aspartate receptor subtype 2B, hNR3, NR3

정제

Purified by antigen affinity column.

등록번호

Q13224

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Glutamate receptor ionotropic, NMDA 2B (GRIN2B) is a ~166 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.

1. Lemke, JR. et al. (2014) Annals of neurology 75, 147-54. PMID: 24272827

2. Adams, DR. et al. (2014) Molecular genetics and metabolism 113, 161-70. PMID: 24863970

3. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626

4. Volgraf, M. et al. (2016) Journal of medicinal chemistry 59, 2760-79. PMID: 26919761

5. Swanger, SA. et al. (2016) American journal of human genetics 99, 1261-1280. PMID: 27839871

6. Ogden, KK. et al. (2017) PLoS genetics 13, e1006536. PMID: 28095420

7. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851

8. Xu, Y. et al. (2024) Cellular and molecular life sciences : CMLS 81, 153. PMID: 38538865

9. Hess, SD. et al. (1996) The Journal of pharmacology and experimental therapeutics 278, 808-16. PMID: 8768735

참고사항

For research use only.

이미지

Western blot

Western blot analysis was performed using anti-GRIN2B polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse brain lysate
Lane 2: Rat brain lysate

참고 문헌

데이터시트

Anti-GRIN2B Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-GRIN2B Polyclonal Antibody (HC330014)

개요

이미지

참고 문헌

데이터시트

SDS

빠른 접근

문의하기