Anti-GSK3A Polyclonal Antibody (HW600014)

Name: Anti-GSK3A Polyclonal Antibody
Brand: abinScience
SKU: HW600014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HW600014

설명

Anti-GSK3A Polyclonal Antibody (HW600014) is a rabbit polyclonal antibody detecting GSK3A in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human GSK3A (Lys99-Ser483).

타겟

GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinase GSK3A

정제

Purified by antigen affinity column.

등록번호

P49840

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Glycogen synthase kinase-3 alpha (GSK3A) is a ~50 kDa protein. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors.

1. Ali, A. et al. (2001) Chemical reviews 101, 2527-40. PMID: 11749387

2. Lee, J. et al. (2007) Diabetes research and clinical practice 77 Suppl 1, S49-57. PMID: 17478001

3. Rayasam, GV. et al. (2009) British journal of pharmacology 156, 885-98. PMID: 19366350

4. Nikoulina, SE. et al. (2000) Diabetes 49, 263-71. PMID: 10868943

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-GSK3A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-GSK3A Polyclonal Antibody (HW600014)

개요

이미지

참고 문헌

데이터시트

SDS

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