中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HW521014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human GSK3B (Met1-Thr420). | ||||||||
| 타겟 | Glycogen synthase kinase-3 beta, GSK3B, Serine/threonine-protein kinase GSK3B, GSK-3 beta | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P49841 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Glycogen synthase kinase-3 beta (GSK3B) is a ~46 kDa protein. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. 1. Frame, S. et al. (2001) Molecular cell 7, 1321-7. PMID: 11430833 2. Dajani, R. et al. (2003) The EMBO journal 22, 494-501. PMID: 12554650 3. Cho, JH. et al. (2004) Journal of neurochemistry 88, 349-58. PMID: 14690523 4. Yin, L. et al. (2006) Science (New York, N.Y.) 311, 1002-5. PMID: 16484495 5. Boyle, WJ. et al. (1991) Cell 64, 573-84. PMID: 1846781 6. Zaoui, K. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 18517-22. PMID: 20937854 7. Beals, CR. et al. (1997) Science (New York, N.Y.) 275, 1930-4. PMID: 9072970 8. Welsh, GI. et al. (1993) The Biochemical journal 294 ( Pt 3), 625-9. PMID: 8397507 | ||||||||
| 참고사항 | For research use only. |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
