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| 카탈로그 번호 | HW458014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-GZMK Polyclonal Antibody (HW458014) is a rabbit polyclonal antibody detecting GZMK in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human GZMK (Ile27-Asn264). | ||||||||
| 타겟 | NK-tryptase-2, Fragmentin-3, Granzyme K, GZMK, Granzyme-3, TRYP2, NK-Tryp-2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P49863 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Granzyme K (GZMK) is a ~28 kDa protein. Serine protease that initiates the GZMK pathway of the complement system, a cascade of proteins directly activated by CD8(+) T-cells that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. GZMK is specifically secreted by CD8(+) T-cells and mediates both recognition and initiation steps of GZMK complement pathway. First acts as a pattern recognition receptor, which specifically recognizes and binds heparan sulfate glycosaminoglycans on the pathogen surface to drive opsonization. It then initiates the complement pathway cascade by catalyzing cleavage and activation of C2 and C4, the next components of the complement pathway. GZMK-mediated complement activation is an important contributor to tissue inflammation. 1. Hameed, A. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 141, 3142-7. PMID: 3262682 2. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882 3. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456 4. Wensink, AC. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 5974-9. PMID: 24711407 5. Mogilenko, DA. et al. (2021) Immunity 54, 99-115.e12. PMID: 33271118 6. Jonsson, AH. et al. (2022) Science translational medicine 14, eabo0686. PMID: 35704599 | ||||||||
| 참고사항 | For research use only. |
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