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| 카탈로그 번호 | HF993014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-H6PD Polyclonal Antibody (HF993014) is a rabbit polyclonal antibody detecting H6PD in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human H6PD (Gln20-Gln526). | ||||||||
| 타겟 | GDH, 6PGL, Glucose 1-dehydrogenase, H6PD, Glucose-6-phosphate dehydrogenase, GDH/6PGL endoplasmic bifunctional protein | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O95479 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | GDH/6PGL endoplasmic bifunctional protein (H6PD) is a ~88 kDa protein. Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway. May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate. The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum. 1. Draper, N. et al. (2003) Nature genetics 34, 434-9. PMID: 12858176 2. Lavery, GG. et al. (2008) The Journal of clinical endocrinology and metabolism 93, 3827-32. PMID: 18628520 3. Lavery, GG. et al. (2013) European journal of endocrinology 168, K19-26. PMID: 23132696 | ||||||||
| 참고사항 | For research use only. |
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